Niagen® is a groundbreaking ingredient that fuels your body from within.
Your health starts with your cells. Everything you do in life depends on the constant cycle of using and regenerating energy throughout your cells. Scientists have known for decades the importance of a coenzyme (a molecule that binds with proteins) called NAD+ (nicotinamide adenine dinucleotide) plays a vital role in the processes of your body. NAD+ helps create cellular energy and support cellular repair throughout your trillions of cells—and organs—throughout your body.
Your NAD+ supply declines with age as well as in response to stressors on your body including alcohol consumption, intense exercise, and lack of sleep. However, in 2004, Dr. Charles Brenner discovered a naturally-occurring vitamin in milk called nicotinamide riboside.
While nicotinamide riboside can be found naturally in certain foods, you cannot get anywhere near the amount you need through a normal diet to effectively increase NAD+.
That is why we created Tru Niagen®, powered by Niagen®, the only patented, broadly studied, and safety-reviewed form of nicotinamide riboside in the world. It's more efficient than NAD+ itself and other NAD+ precursors.
Niagen, our patented form of this micronutrient, is clinically proven to increase NAD+ levels by up to 150%.
Niagen has achieved regulatory acceptance for use in supplements by the US FDA.
In addition to receiving approval for use in medical foods by the Brazilian Health Regulatory Agency (ANVISA), Niagen® has also been approved for use in food supplements by the European Commission, complementary medicines by the Therapeutic Goods Administration of Australia (TGA), and medical foods by the Food Standards Australia New Zealand (FSANZ). Tru Niagen® has also been approved by Health Canada as a Natural Health Product.
Niagen® is backed by 35+ clinical studies that demonstrate safety and/or efficacy.
Our published, peer-reviewed human clinical studies provide our foundation of scientific evidence. Over 75% of registered ongoing or completed nicotinamide riboside trials use Niagen®. Here are five of our studies, just to name a few.
One of the most well researched patented supplements on the market.2
“The power of this form of vitamin B3 to raise NAD+ impressed me back in 2004 when I discovered it. Now, 14 years and 42 publications on NAD+ later, its unique ability to restore balance in the face of metabolic stress continues to amaze me.”
Charles Brenner, Ph.D., ChromaDex’s Chief Scientific Advisor
The scientist who discovered nicotinamide riboside's utility as a micronutrient.
Niagen® is clinically proven to safely and effectively boost NAD+ levels, backed by science you can trust.
Two randomized, double-blind, placebo-controlled studies with healthy subjects looked at the dose response of 1000mg of Tru Niagen supplementation on NAD+ levels. Results show when Tru Niagen is supplemented orally, there was an average of a 150% increase in NAD+ in 3 weeks with 1000mg, compared to a 50% increase in NAD+ with 300mg. Read the study published in Nature here.
Blog posts
Meet CD38: The Enzyme That Affects NAD+ and How Fast Your Cells Age
The enzyme CD38 is necessary for immune regulation and cell signaling, but its overexpression depletes NAD+ stores. NAD+ is a critical coenzyme for cellular functioning, the levels of which decline...
The Double Action of Niagen®: Boosting NAD+ While Inhibiting CD38
An exciting preclinical study uncovers a new physiological role of NR related to the enzyme CD38. Overexpression of CD38 degrades NAD+, contributing to low NAD+ levels. This study finds that...