In addition to 10 published human studies, leading universities continue to study daily supplementation with Niagen® in humans for a variety of health outcomes. ChromaDex, the makers of Tru Niagen®, has engaged in over 200 research collaborations around the world with leading universities and institutions.

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Metabolic Stress takes many forms, depleting your NAD+. Start repair with cellular care.*

Your NAD+ declines from aging, immune stress, intense exercise, sleep disruption, and many other lifestyle stressors. Tru Niagen® is a cellular nutrient that is proven to increase NAD+ levels by 40-50%.

  • Aging

  • Intense Exercise

  • Overeating

  • Sleep Disruption

  • Immune Stress

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Our Ingredient vs. Others

Niagen® is the patented, safety-reviewed form of nicotinamide riboside, a cellular nutrient designed to permeate the cell wall with ease and nourish the cell more efficiently than any other NAD+ supplement.*

Our Ingredient vs. Others
NiacinNiacinamideNMNNIAGEN®/
TRU NIAGEN®
Boosts NAD+ checkedcheckedcheckedchecked
Does not cause skin flushing uncheckedcheckedcheckedchecked
Does not suppress sirtuin activity checkeduncheckedcheckedchecked
Human clinical trials proving increased NAD+ levels checkedcheckeduncheckedchecked
FDA notified as GRAS (Generally Recognized as Safe) checkedcheckeduncheckedchecked
Successfully reviewed under the FDA NDI program n/an/auncheckedchecked
NSF Certified for Sport® seal (does not contain over 272 banned substances) uncheckeduncheckeduncheckedchecked
Approved for sale by government bodies in Canada, the European Union and Australia checkedcheckeduncheckedchecked

Customer Reviews

All our reviews are written and provided by real customers. However, FDA and FTC regulations prohibit us from posting every review that is submitted.

Frequently Asked Questions

Have a question not answered here? Check out our FAQs.


As with any supplement or new health routine, your experiences will vary depending on your age, diet, exercise, and sleep habits. Tru Niagen® will start increasing NAD levels shortly after you take it and will continue to maintain those elevated NAD levels with regular supplementation. It may take some time to feel the benefits of increased NAD (promoting cellular repair, increasing cellular energy, etc.), but ultimately Tru Niagen® is helping your cells remain energized and resilient in the face of everyday stresses.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


The B3 vitamins have one thing in common: they are all building blocks cells can use to make more NAD. Nicotinic acid, nicotinamide, and nicotinamide riboside can all be turned into NAD, but cells use different recipes that require different amounts of energy and numbers of steps to make NAD out of each B3. Some B3s also come with some unwelcome side effects: nicotinic acid can cause an uncomfortable flushing response while nicotinamide can inhibit the activity of cellular health-promoting sirtuins.

We’ve written an entire post about the differences between NR and the other B3 vitamins, you can read it here.


Tru Niagen® increases levels of a key cellular resource known as NAD. Nicotinamide adenine dinucleotide (or NAD) is found in every living cell and is essential to a healthy cellular metabolism. While NAD is produced during energy generation, it’s also constantly being consumed. We use NAD whenever we eat, drink, sleep, or breathe. Studies also show our NAD levels decline as we age by as much as 50% between the ages of 40–60. Because NAD is essential to energy generation, the less we have of it, the harder it is for our cells to stay healthy as we age.

In 2004, Dr. Charles Brenner discovered that a unique form of vitamin B3 (nicotinamide riboside, or NR) was also an NAD precursor. Since then, multiple human clinical trials have shown NR safely and effectively increases NAD.

Tru Niagen® contains the patented and only known FDA-safety notified form of nicotinamide riboside, delivered straight to your door.


Explore the Science In Our Blog

What is a coenzyme? Why is NAD+ important? Learn more from our blog to help better understand the core of our product. We take complex science and distill it down to everyday language, enriching you with knowledge on cellular health.

NAD+ molecule NAD+ molecule NAD+ molecule NAD+ molecule NAD+ molecule

NAD: What Is It and How Does It Affect Aging?

Understand the inner workings behind the coenzyme NAD+ and why it’s essential for your health.
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molecular model of nicotinamide riboside molecular model of nicotinamide riboside molecular model of nicotinamide riboside molecular model of nicotinamide riboside molecular model of nicotinamide riboside

Nicotinamide Riboside (NR): What Is It?

Explore nicotinamide riboside (NR), the groundbreaking micronutrient behind Tru Niagen® that's making headlines as the "healthy aging" vitamin.
Explore
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